Ticrynafen and hydrochlorothiazide a comparison in hypertensive patients with renal impairment

Emmerson B.T., Renshaw P.J., Ravenscroft P.J., Denham I. and Schey S. (1982) Ticrynafen and hydrochlorothiazide a comparison in hypertensive patients with renal impairment. European Journal of Clinical Pharmacology, 22 3: 203-206. doi:10.1007/BF00545215


Author Emmerson B.T.
Renshaw P.J.
Ravenscroft P.J.
Denham I.
Schey S.
Title Ticrynafen and hydrochlorothiazide a comparison in hypertensive patients with renal impairment
Journal name European Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0031-6970
Publication date 1982-01-01
Sub-type Article (original research)
DOI 10.1007/BF00545215
Volume 22
Issue 3
Start page 203
End page 206
Total pages 4
Publisher Springer-Verlag
Subject 3000 Pharmacology, Toxicology and Pharmaceutics
2736 Pharmacology (medical)
Abstract The efficacy of ticrynafen in the treatment of hypertension in patients with moderate renal impairment was compared with that of hydrochlorothiazide in a randomised, double-blind crossover trial in eleven subjects with renal insufficiency. Significant reductions in blood pressure occurred with both treatments, with the maximum responses occurring at different time intervals and to different degrees in individual patients. Thus, although ticrynafen caused a significant reduction in blood pressure in this group of hypertensive patients with renal insufficiency, it was not consistently different from that which could be achieved with hydrochlorothiazide. Ticrynafen also significantly reduced the serum uric acid concentration, compared with a significant rise with hydrochlorothiazide. No major biochemical abnormalities or side-effects were encountered in any subject. Thus, in these patients with renal insufficiency, ticrynafen still demonstrated a uricosuric effect as well as a useful anti-hypertensive action.
Keyword diuretic
hydrochlorothiazide
hypertension
renal impairment
ticrynafen
uricosuria
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 16 Aug 2016, 11:26:34 EST by System User