Two-dimensional non-carbonaceous materials-enabled efficient photothermal cancertherapy

Chen, Yu, Wang, Lianzhou and Shi, Jianlin (2016) Two-dimensional non-carbonaceous materials-enabled efficient photothermal cancertherapy. Nano Today, 11 3: 292-308. doi:10.1016/j.nantod.2016.05.009

Author Chen, Yu
Wang, Lianzhou
Shi, Jianlin
Title Two-dimensional non-carbonaceous materials-enabled efficient photothermal cancertherapy
Journal name Nano Today   Check publisher's open access policy
ISSN 1748-0132
Publication date 2016-06-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.nantod.2016.05.009
Open Access Status Not Open Access
Volume 11
Issue 3
Start page 292
End page 308
Total pages 17
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
Based on the unique two-dimensional (2D) planar nanostructure with atomic-thin thickness, abundant composition variations and the corresponding exceptional physiochemical/biological performances, the emerging inorganic 2D nanomaterials with high biocompatibility have been becoming one of the most promising material nanosystems of great potentials for applications in biomedicine. This review focuses on the unique photothermal-conversion property of several new representative 2D nanomaterials beyond graphene for photothermal conversion-based tumor hyperthermia and theranostic biomedicine, including transition metal dichalcogenides (TMDCs, such as MoS2, WS2, TiS2 and Bi2Se3), black phosphorous (P), metal Pd nanosheets and their composite nanosheets. Based on high photothermal-conversion efficiency of these 2D nanomaterials, this review first highlights the design, synthesis and surface functionalization of 2D nanomaterials for photothermal therapy (PTT) ablation of cancer cells/tissues. The representative strategies of functionalizing these 2D nanomaterials for imaging-guided PTT and PTT-based synergistic cancer therapy are then discussed. The preliminary progresses on biosafety evaluation of these 2D nanomaterials were also briefly summarized and discussed. Finally, we discussed the state-of-art unsolved critical issues and challenges, and outlooked further research directions of 2D nanomaterials for potential clinical translation for PTT tumor ablation. It is believed that the fast development and promising performance of these biocompatible 2D materials can provide a highly efficient nanoplatform for combating cancer by hyperthermia.
Keyword Two-dimensional materials
Photothermal therapy
Cancer therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: School of Chemical Engineering Publications
HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 16 Aug 2016, 02:03:50 EST by Professor Lianzhou Wang on behalf of School of Chemical Engineering