Revisiting the scissor-like mechanism of activation for the erythropoietin receptor

Corbett, Michael S. P., Poger, David and Mark, Alan E. (2016) Revisiting the scissor-like mechanism of activation for the erythropoietin receptor. FEBS Letters, 590 18: 3083-3088. doi:10.1002/1873-3468.12340


Author Corbett, Michael S. P.
Poger, David
Mark, Alan E.
Title Revisiting the scissor-like mechanism of activation for the erythropoietin receptor
Journal name FEBS Letters   Check publisher's open access policy
ISSN 1873-3468
0014-5793
Publication date 2016-08-04
Year available 2016
Sub-type Article (original research)
DOI 10.1002/1873-3468.12340
Open Access Status Not Open Access
Volume 590
Issue 18
Start page 3083
End page 3088
Total pages 13
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Subject 1315 Structural Biology
1304 Biophysics
1303 Biochemistry
1312 Molecular Biology
1311 Genetics
1307 Cell Biology
Abstract An interpretation of alternative crystal structures of the erythropoietin receptor, with and without ligand, led to the proposal of a scissor-like mechanism of activation. This model has been propagated in the literature and is still being used to interpret crystal structures of related type-I cytokine receptors. Here, we assess whether the model remains compatible with current knowledge on the family of type-I cytokine receptors, and consider whether the model, as initially presented, is truly supported by the crystal structures on which it was originally based.
Keyword Erythropoietin
X-ray crystallography
Receptor activation
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID APP1084797
DP110100327
DP130102153
LE120100181
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
 
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Created: Fri, 12 Aug 2016, 21:20:31 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences