Interfacial engineering for silica nanocapsules

Wibowo, David, Hui, Yue, Middelberg, Anton P. J. and Zhao, Chun-Xia (2016) Interfacial engineering for silica nanocapsules. Advances in Colloid and Interface Science, 236 83-100. doi:10.1016/j.cis.2016.08.001

Author Wibowo, David
Hui, Yue
Middelberg, Anton P. J.
Zhao, Chun-Xia
Title Interfacial engineering for silica nanocapsules
Journal name Advances in Colloid and Interface Science   Check publisher's open access policy
ISSN 0001-8686
Publication date 2016-10-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.cis.2016.08.001
Open Access Status Not Open Access
Volume 236
Start page 83
End page 100
Total pages 18
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 3110 Surfaces and Interfaces
1606 Physical and Theoretical Chemistry
1505 Colloid and Surface Chemistry
Abstract Silica nanocapsules have attracted significant interest due to their core–shell hierarchical structure. The core domain allows the encapsulation of various functional components such as drugs, fluorescent and magnetic nanoparticles for applications in drug delivery, imaging and sensing, and the silica shell with its unique properties including biocompatibility, chemical and physical stability, and surface-chemistry tailorability provides a protection layer for the encapsulated cargo. Therefore, significant effort has been directed to synthesize silica nanocapsules with engineered properties, including size, composition and surface functionality, for various applications. This review provides a comprehensive overview of emerging methods for the manufacture of silica nanocapsules, with a special emphasis on different interfacial engineering strategies. The review starts with an introduction of various manufacturing approaches of silica nanocapsules highlighting surface engineering of the core template nanomaterials (solid nanoparticles, liquid droplets, and gas bubbles) using chemicals or biomolecules which are able to direct nucleation and growth of silica at the boundary of two phase interfaces (solid–liquid, liquid–liquid, and gas–liquid). Next, surface functionalization of silica nanocapsules is presented. Furthermore, strategies and challenges of encapsulating active molecules (pre-loading and post-loading approaches) in these capsular systems are critically discussed. Finally, applications of silica nanocapsules in controlled release, imaging, and theranostics are reviewed.
Keyword Silica
Controlled release
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID DP150100798
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
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Created: Fri, 12 Aug 2016, 00:41:45 EST by David Wibowo on behalf of Aust Institute for Bioengineering & Nanotechnology