The identification of lymphoid cell subpopulations in sections of human lymphoid tissue and gingivitis in children using monoclonal antibodies

Seymour G.J., Crouch M.S., Powell R.N., Brooks D., Beckman I., Zola H., Bradley J. and Burns G.F. (1982) The identification of lymphoid cell subpopulations in sections of human lymphoid tissue and gingivitis in children using monoclonal antibodies. Journal of Periodontal Research, 17 3: 247-256. doi:10.1111/j.1600-0765.1982.tb01151.x


Author Seymour G.J.
Crouch M.S.
Powell R.N.
Brooks D.
Beckman I.
Zola H.
Bradley J.
Burns G.F.
Title The identification of lymphoid cell subpopulations in sections of human lymphoid tissue and gingivitis in children using monoclonal antibodies
Journal name Journal of Periodontal Research   Check publisher's open access policy
ISSN 0022-3484
Publication date 1982-01-01
Sub-type Article (original research)
DOI 10.1111/j.1600-0765.1982.tb01151.x
Open Access Status Not yet assessed
Volume 17
Issue 3
Start page 247
End page 256
Total pages 10
Language eng
Subject 3500 Dentistry
Abstract Monoclonal antibodies made against lymphocyte differentiation antigens were used to characterize phenotypically the lymphoid cell subpopulations in sections of human lymphoid tissue and inflamed gingival tissue associated with the deciduous dentition in children. Four monoclonal antibodies designated FMC 1, FMC 4, FMC 7, and UCHT1 were used. These antibodies are specific for B‐cells, p28,33 (la‐like) antigen, a B‐cell subset, and peripheral T‐cells respectively. FMC 1 and FMC 4 positive cells (B‐cells) were found mainly in the secondary follicles while UCHT1 positive cells (T‐cells) were found in the parafollicular areas of human tonsils. Cells in some, but not all, secondary follicles in the tonsils were FMC 7 positive. In the gingival tissue only 12.6 % of the infiltrating cells were FMC 1 positive, 12.2 % were FMC 4 positive, and 4.8 % FMC 7 positive. On the other hand over 75 % of cells appeared to be UCHT1 positive. These results indicate that the majority of inflammatory cells in gingivitis associated with the deciduous dentition in children have the phenotype B‐cell antigen‐/p28,33 (lalike) antigen‐/B‐cell subset antigen‐ and possibly T‐cell antigen+. Such a phenotype is, at least by exclusion, suggestive of T‐cells and as such confirms earlier studies using T‐cell enzyme markers. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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