Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle

Daetwyler, Hans D., Capitan, Aurelien, Pausch, Hubert, Stothard, Paul, Van Binsbergen, Rianne, Brondum, Rasmus F., Liao, Xiaoping, Djari, Anis, Rodriguez, Sabrina C., Grohs, Cecile, Esquerre, Diane, Bouchez, Olivier, Rossignol, Marie-Noelle, Klopp, Christophe, Rocha, Dominique, Fritz, Sebastien, Eggen, Andre, Bowman, Phil J., Coote, David, Chamberlain, Amanda J., Anderson, Charlotte, VanTassell, Curt P., Hulsegge, Ina, Goddard, Mike E., Guldbrandtsen, Bernt, Lund, Mogens S., Veerkamp, Roel F., Boichard, Didier A., Fries, Ruedi and Hayes, Ben J. (2014) Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle. Nature Genetics, 46 8: 858-865. doi:10.1038/ng.3034

Author Daetwyler, Hans D.
Capitan, Aurelien
Pausch, Hubert
Stothard, Paul
Van Binsbergen, Rianne
Brondum, Rasmus F.
Liao, Xiaoping
Djari, Anis
Rodriguez, Sabrina C.
Grohs, Cecile
Esquerre, Diane
Bouchez, Olivier
Rossignol, Marie-Noelle
Klopp, Christophe
Rocha, Dominique
Fritz, Sebastien
Eggen, Andre
Bowman, Phil J.
Coote, David
Chamberlain, Amanda J.
Anderson, Charlotte
VanTassell, Curt P.
Hulsegge, Ina
Goddard, Mike E.
Guldbrandtsen, Bernt
Lund, Mogens S.
Veerkamp, Roel F.
Boichard, Didier A.
Fries, Ruedi
Hayes, Ben J.
Title Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1546-1718
Publication date 2014-08-01
Year available 2014
Sub-type Article (original research)
DOI 10.1038/ng.3034
Open Access Status Not yet assessed
Volume 46
Issue 8
Start page 858
End page 865
Total pages 8
Place of publication New York, United States
Publisher Nature Publishing Group
Language eng
Abstract The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle.
Keyword Genetics & Heredity
Genetics & Heredity
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 0315527B
12-132452 (GenSAP)
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Alliance for Agriculture and Food Innovation
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Citation counts: TR Web of Science Citation Count  Cited 217 times in Thomson Reuters Web of Science Article | Citations
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