Fitness is independently associated with central hemodynamics in metabolic syndrome

Ramos, J.S., Ramos, M.V., Dalleck, L.C., Borrani, F., Walker, K.B., Fassett, R.G., Sharman, J.E. and Coombes, J.S. (2016) Fitness is independently associated with central hemodynamics in metabolic syndrome. Medicine and Science in Sports and Exercise, 48 8: 1539-1547. doi:10.1249/MSS.0000000000000916

Author Ramos, J.S.
Ramos, M.V.
Dalleck, L.C.
Borrani, F.
Walker, K.B.
Fassett, R.G.
Sharman, J.E.
Coombes, J.S.
Title Fitness is independently associated with central hemodynamics in metabolic syndrome
Journal name Medicine and Science in Sports and Exercise   Check publisher's open access policy
ISSN 1530-0315
Publication date 2016-08-01
Year available 2016
Sub-type Article (original research)
DOI 10.1249/MSS.0000000000000916
Open Access Status Not Open Access
Volume 48
Issue 8
Start page 1539
End page 1547
Total pages 9
Place of publication Philadelphia, United States
Publisher Lippincott Williams and Wilkins
Language eng
Formatted abstract
Purpose: Fit individuals with metabolic syndrome (MetS) have lower mortality risk compared with less fit counterparts, despite the presence of obesity as a component of the syndrome. To understand the importance of fitness in treating this condition, we examined the association of fitness and fatness with central hemodynamic indices that are known independent predictors of cardiovascular events.

Methods: Sixty-eight individuals with MetS participated in this cross-sectional study. Central hemodynamics is calculated from radial applanation tonometry and comprised aortic reservoir pressure, backward pressure wave (Pb), reflection magnitude (RM), and augmentation index at 75 bpm (AIx75). Cardiorespiratory fitness (CRF) and body fat percentage (BF%) were determined via indirect calorimetry during maximal exercise testing and dual-energy x-ray absorptiometry, respectively.

Results: CRF was inversely associated with aortic reservoir pressure (r = -0.29, P = 0.02), Pb (r = -0.42, P < 0.001), RM (r = -0.48, P < 0.001), and AIx75 (r = -0.65, P < 0.001). BF% was also correlated with AIx75 (r = 0.37, P < 0.05) and RM (r = 0.36, P < 0.005) but at a weaker association compared with CRF. Multiple regression analysis revealed CRF as a predictor of aortic reservoir pressure ([beta] = -0.52, P = <0.01), Pb ([beta] = -0.41, P < 0.03), and AIx75 ([beta] = -0.45, P = 0.01), independent of BF% and other confounding factors.

Conclusions: CRF predicts central hemodynamics independent of BF% and other confounding factors. This suggests that CRF improvement may be a higher priority when compared with fat loss for lowering the risk of cardiovascular mortality in MetS individuals.
Keyword Aortic reservoir function
Arterial stiffness
Arterioventricular coupling
VO 2peak
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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