Moving GLUT4: The biogenesis and trafficking of GLUT4 storage vesicles

Rea S. and James D.E. (1997) Moving GLUT4: The biogenesis and trafficking of GLUT4 storage vesicles. Diabetes, 46 11: 1667-1677. doi:10.2337/diab.46.11.1667


Author Rea S.
James D.E.
Title Moving GLUT4: The biogenesis and trafficking of GLUT4 storage vesicles
Journal name Diabetes   Check publisher's open access policy
ISSN 0012-1797
Publication date 1997-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2337/diab.46.11.1667
Volume 46
Issue 11
Start page 1667
End page 1677
Total pages 11
Publisher American Diabetes Association Inc.
Language eng
Subject 2724 Internal Medicine
2712 Endocrinology, Diabetes and Metabolism
Abstract The GLUT4 system in muscle and fat cells plays an important role in whole-body glucose homeostasis. Insulin stimulates the translocation of GLUT4 from an intracellular storage compartment to the cell surface. The nature of this compartment remains largely unknown. We review recent studies describing the biogenesis and molecular constituents of the GLUT4 storage compartment and conclude that it is segregated from the endosomal and biosynthetic pathways. Further, we present evidence to suggest that the GLUT4 storage compartment moves directly to the plasma membrane in response to insulin and, hence, is analogous to small synaptic vesicles in neurons. We propose that the GLUT4 storage compartment be referred to as GLUT4 storage vesicles or GSVs.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import
 
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Created: Tue, 26 Jul 2016, 13:12:07 EST by System User