Fine genetic mapping of the gene for nevoid basal cell carcinoma syndrome

Wicking C., Berkman J., Wainwright B. and Chenevix-Trench G. (1994) Fine genetic mapping of the gene for nevoid basal cell carcinoma syndrome. Genomics, 22 3: 505-511. doi:10.1006/geno.1994.1423


Author Wicking C.
Berkman J.
Wainwright B.
Chenevix-Trench G.
Title Fine genetic mapping of the gene for nevoid basal cell carcinoma syndrome
Journal name Genomics   Check publisher's open access policy
ISSN 0888-7543
Publication date 1994-01-01
Year available 1994
Sub-type Article (original research)
DOI 10.1006/geno.1994.1423
Open Access Status Not yet assessed
Volume 22
Issue 3
Start page 505
End page 511
Total pages 7
Place of publication SAN DIEGO
Publisher ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
Language eng
Subject 1311 Genetics
Abstract Nevoid basal cell carcinoma syndrome (NBCCS, or Gorlin syndrome) is a cancer predisposition syndrome characterized by multiple basal cell carcinomas and diverse developmental defects. The gene responsible for NBCCS, which is most likely to be a tumor suppressor gene, has previously been mapped to 9q22.3-q31 in a 12-cM interval between the microsatellite marker loci D9S12.1 and D9S109. Combined multipoint and haplotype analyses of additional polymorphisms in this region in our collection of Australasian pedigrees have further refined the localization of the gene to between the markers D9S196 and D9S180, an interval reported to be approximately 2 cM. (C) 1994 Academic Press, Inc.
Keyword Dinucleotide Repeat Polymorphism
Gorlin Syndrome
Linkage Analysis
Human Genome
Locus
Localization
Chromosome-9
Families
Map
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Citation counts: TR Web of Science Citation Count  Cited 44 times in Thomson Reuters Web of Science Article | Citations
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