Risk factors for metachronous colorectal cancer following a primary colorectal cancer: a prospective cohort study

Jayasekara, Harindra, Reece, Jeanette C., Buchanan, Daniel D., Rosty, Christophe, Dashti, S. Ghazaleh, Ouakrim, Driss Ait, Winship, Ingrid M., Macrae, Finlay A., Boussioutas, Alex, Giles, Graham G., Ahnen, Dennis J., Lowery, Jan, Casey, Graham, Haile, Robert W., Gallinger, Steven, Le Marchand, Loic, Newcomb, Polly A., Lindor, Noralane M., Hopper, John L., Parry, Susan, Jenkins, Mark A. and Win, Aung Ko (2016) Risk factors for metachronous colorectal cancer following a primary colorectal cancer: a prospective cohort study. International Journal of Cancer, 139 5: 1081-1090. doi:10.1002/ijc.30153

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Author Jayasekara, Harindra
Reece, Jeanette C.
Buchanan, Daniel D.
Rosty, Christophe
Dashti, S. Ghazaleh
Ouakrim, Driss Ait
Winship, Ingrid M.
Macrae, Finlay A.
Boussioutas, Alex
Giles, Graham G.
Ahnen, Dennis J.
Lowery, Jan
Casey, Graham
Haile, Robert W.
Gallinger, Steven
Le Marchand, Loic
Newcomb, Polly A.
Lindor, Noralane M.
Hopper, John L.
Parry, Susan
Jenkins, Mark A.
Win, Aung Ko
Title Risk factors for metachronous colorectal cancer following a primary colorectal cancer: a prospective cohort study
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 1097-0215
Publication date 2016-09-01
Year available 2016
Sub-type Article (original research)
DOI 10.1002/ijc.30153
Open Access Status File (Author Post-print)
Volume 139
Issue 5
Start page 1081
End page 1090
Total pages 10
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Subject 2730 Oncology
1306 Cancer Research
Abstract Individuals diagnosed with colorectal cancer (CRC) are at risk of developing a metachronous CRC. We examined the associations between personal, tumour-related and lifestyle risk factors, and risk of metachronous CRC. A total of 7,863 participants with incident colon or rectal cancer who were recruited in the USA, Canada and Australia to the Colon Cancer Family Registry during 1997-2012, except those identified as high-risk, for example, Lynch syndrome, were followed up approximately every 5 years. We estimated the risk of metachronous CRC, defined as the first new primary CRC following an interval of at least one year after the initial CRC diagnosis. Observation time started at the age at diagnosis of the initial CRC and ended at the age at diagnosis of the metachronous CRC, last contact or death whichever occurred earliest, or were censored at the age at diagnosis of any metachronous colorectal adenoma. Cox regression was used to derive hazard ratios (HRs) and 95% confidence intervals (CIs). During a mean follow-up of 6.6 years, 142 (1.81%) metachronous CRCs were diagnosed (mean age at diagnosis 59.8; incidence 2.7/1,000 person-years). An increased risk of metachronous CRC was associated with the presence of a synchronous CRC (HR = 2.73; 95% CI: 1.30-5.72) and the location of cancer in the proximal colon at initial diagnosis (compared with distal colon or rectum, HR = 4.16; 95% CI: 2.80-6.18). The presence of a synchronous CRC and the location of the initial CRC might be useful for deciding the intensity of surveillance colonoscopy for individuals diagnosed with CRC.
Keyword Colorectal cancer
Risk factors
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID HHSN261201000035C
U01 CA074799
U24 CA074783
N01 CN067009
U24 CA074794
U24 CA074806
U24 CA097735
U01 CA074794
U01 CA097735
K05 CA152715
UM1 CA167551
U58 DP003862
U01 CA074783
U24 CA074799
U01 CA074806
U24 CA074800
U01 CA074800
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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