HCV-related liver and lymphoproliferative diseases: association with polymorphisms of IL28B and TLR2

De Re, Valli, De Zorzi, Mariangela, Caggiari, Laura, Lauletta, Gianfranco, Tornesello, Maria Lina, Fognani, Elisa, Miorin, Marta, Racanelli, Vito, Quartuccio, Luca, Gragnani, Laura, Russi, Sabino, Pavone, Fabio, Ghersetti, Michela, Costa, Elena Garlatti, Casarin, Pietro, Bomben, Riccardo, Mazzaro, Cesare, Basaglia, Giancarlo, Berretta, Massimiliano, Vaccher, Emanuela, Izzo, Francesco, Buonaguro, Franco Maria, De Vita, Salvatore, Zignego, Anna Linda, De Paoli, Paolo and Dolcetti, Riccardo (2016) HCV-related liver and lymphoproliferative diseases: association with polymorphisms of IL28B and TLR2. Oncotarget, 7 25: 37487-37497. doi:10.18632/oncotarget.9303

Author De Re, Valli
De Zorzi, Mariangela
Caggiari, Laura
Lauletta, Gianfranco
Tornesello, Maria Lina
Fognani, Elisa
Miorin, Marta
Racanelli, Vito
Quartuccio, Luca
Gragnani, Laura
Russi, Sabino
Pavone, Fabio
Ghersetti, Michela
Costa, Elena Garlatti
Casarin, Pietro
Bomben, Riccardo
Mazzaro, Cesare
Basaglia, Giancarlo
Berretta, Massimiliano
Vaccher, Emanuela
Izzo, Francesco
Buonaguro, Franco Maria
De Vita, Salvatore
Zignego, Anna Linda
De Paoli, Paolo
Dolcetti, Riccardo
Title HCV-related liver and lymphoproliferative diseases: association with polymorphisms of IL28B and TLR2
Journal name Oncotarget   Check publisher's open access policy
ISSN 1949-2553
Publication date 2016-05-11
Year available 2016
Sub-type Article (original research)
DOI 10.18632/oncotarget.9303
Open Access Status DOI
Volume 7
Issue 25
Start page 37487
End page 37497
Total pages 11
Place of publication Albany, NY, United States
Publisher Impact Journals LLC
Language eng
Formatted abstract
To explore the relationship between innate immunity and hepatitis C Virus (HCV) in determining the risk of cirrhosis (CIR), hepatocellular carcinoma (HCC), mixed cryoglobulinemia syndrome (MCS) and non-Hodgkin lymphoma (NHL), we investigated the impact of the toll-like receptor-2 (TLR2) and interleukin-28B (IL28B) genetic variants. TLR2 -174 del variant was associated with TLR2 expression and with specific downstream molecules that drive the expression of different interleukins; rs12979860 Il28B was important in response to interferon-treatment and in spontaneous clearance of HCV. The risk for liver and lymphoproliferative diseases in HCV progression was clarified by stratifying 862 HCV-positive patients into groups based on liver (CIR, HCC) and lymphoproliferative HCV-related diseases (MCS, NHL) and compared with chronic HCV (CHC) infection. Analysis of TLR2-IL28B haplotypes showed an association of wild type haplotype with the lymphoproliferative diseases (OR 1.77, p = 0.029) and a slight increase in HCV viral load (HR 1.38, p = 0.054). Wild type haplotype (TLR2 ins/ins-IL28B C/C) was also found associated with older age in patients with an hepatic diseases (in CIR and in HCC p = 0.038 and p = 0.020, respectively) supporting an effect of innate immunity in the liver disease progression. TLR2 and IL28B polymorphisms in combination showed a role in the control of HCV viral load and different HCV disease progression.
Keyword HCV
Immunology and microbiology section
Immune response
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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UQ Diamantina Institute Publications
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