Pediatric post-thrombotic syndrome in children: Toward the development of a new diagnostic and evaluative measurement tool

Avila, M. L., Brandão, L. R., Williams, S., Ward, L. C., Montoya, M. I., Stinson, J., Kiss, A., Lara-Corrales, I. and Feldman, B. M. (2016) Pediatric post-thrombotic syndrome in children: Toward the development of a new diagnostic and evaluative measurement tool. Thrombosis Research, 144 184-191. doi:10.1016/j.thromres.2016.06.035

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Author Avila, M. L.
Brandão, L. R.
Williams, S.
Ward, L. C.
Montoya, M. I.
Stinson, J.
Kiss, A.
Lara-Corrales, I.
Feldman, B. M.
Title Pediatric post-thrombotic syndrome in children: Toward the development of a new diagnostic and evaluative measurement tool
Journal name Thrombosis Research   Check publisher's open access policy
ISSN 0049-3848
1879-2472
Publication date 2016-08-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.thromres.2016.06.035
Open Access Status File (Author Post-print)
Volume 144
Start page 184
End page 191
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 2720 Hematology
Abstract Objective Our goal was to conduct the item generation and piloting phases of a new discriminative and evaluative tool for pediatric post-thrombotic syndrome. Methods We followed a formative model for the development of the tool, focusing on the signs/symptoms (items) that define post-thrombotic syndrome. For item generation, pediatric thrombosis experts and subjects diagnosed with extremity post-thrombotic syndrome during childhood nominated items. In the piloting phase, items were cross-sectionally measured in children with limb deep vein thrombosis to examine item performance. Result Twenty-three experts and 16 subjects listed 34 items, which were then measured in 140 subjects with previous diagnosis of limb deep vein thrombosis (70 upper extremity and 70 lower extremity). The items with strongest correlation with post-thrombotic syndrome severity and largest area under the curve were pain (in older children), paresthesia, and swollen limb for the upper extremity group, and pain (in older children), tired limb, heaviness, tightness and paresthesia for the lower extremity group. Conclusion The diagnostic properties of the items and their correlations with post-thrombotic syndrome severity varied according to the assessed venous territory. The information gathered in this study will help experts decide which item should be considered for inclusion in the new tool.
Formatted abstract
Objective
Our goal was to conduct the item generation and piloting phases of a new discriminative and evaluative tool for pediatric post-thrombotic syndrome.

Methods
We followed a formative model for the development of the tool, focusing on the signs/symptoms (items) that define post-thrombotic syndrome. For item generation, pediatric thrombosis experts and subjects diagnosed with extremity post-thrombotic syndrome during childhood nominated items. In the piloting phase, items were cross-sectionally measured in children with limb deep vein thrombosis to examine item performance.

Result
Twenty-three experts and 16 subjects listed 34 items, which were then measured in 140 subjects with previous diagnosis of limb deep vein thrombosis (70 upper extremity and 70 lower extremity). The items with strongest correlation with post-thrombotic syndrome severity and largest area under the curve were pain (in older children), paresthesia, and swollen limb for the upper extremity group, and pain (in older children), tired limb, heaviness, tightness and paresthesia for the lower extremity group.

Conclusion
The diagnostic properties of the items and their correlations with post-thrombotic syndrome severity varied according to the assessed venous territory. The information gathered in this study will help experts decide which item should be considered for inclusion in the new tool.
Keyword Child
Deep vein thrombosis
Lower extremity
Sign
Symptom
Upper extremity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 15 Jul 2016, 21:58:49 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences