Verbal initiation, suppression, and strategy use and the relationship with clinical symptoms in schizophrenia

Martin, Andrew K., Gibson, Emily C., Mowry, Bryan and Robinson,Gail A. (2016) Verbal initiation, suppression, and strategy use and the relationship with clinical symptoms in schizophrenia. Journal of the International Neuropsychological Society, 22 7: 735-743. doi:10.1017/S1355617716000552

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Author Martin, Andrew K.
Gibson, Emily C.
Mowry, Bryan
Robinson,Gail A.
Title Verbal initiation, suppression, and strategy use and the relationship with clinical symptoms in schizophrenia
Journal name Journal of the International Neuropsychological Society   Check publisher's open access policy
ISSN 1355-6177
Publication date 2016-08-01
Year available 2016
Sub-type Article (original research)
DOI 10.1017/S1355617716000552
Open Access Status File (Publisher version)
Volume 22
Issue 7
Start page 735
End page 743
Total pages 9
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Language eng
Formatted abstract
Objectives: Individuals with schizophrenia have difficulties on measures of executive functioning such as initiation and suppression of responses and strategy development and implementation. The current study thoroughly examines performance on the Hayling Sentence Completion Test (HSCT) in individuals with schizophrenia, introducing novel analyses based on initiation errors and strategy use, and association with lifetime clinical symptoms. Methods: The HSCT was administered to individuals with schizophrenia (N=77) and age- and sex-matched healthy controls (N=45), along with background cognitive tests. The standard HSCT clinical measures (initiation response time, suppression response time, suppression errors), composite initiation and suppression error scores, and strategy-based responses were calculated. Lifetime clinical symptoms [formal thought disorder (FTD), positive, negative] were calculated using the Lifetime Dimensions of Psychosis Scale. Results: After controlling for baseline cognitive differences, individuals with schizophrenia were significantly impaired on the suppression response time and suppression error scales. For the novel analyses, individuals with schizophrenia produced a greater number of initiation errors and subtly wrong errors, and produced fewer responses indicative of developing an appropriate strategy. Strategy use was negatively correlated with FTD symptoms in individuals with schizophrenia. Conclusions: The current study provides further evidence for deficits in the initiation and suppression of verbal responses in individuals with schizophrenia. Moreover, an inability to attain a strategy at least partly contributes to increased semantically connected errors when attempting to suppress responses. The association between strategy use and FTD points to the involvement of executive deficits in disorganized speech in schizophrenia.
Keyword Schizophrenia
Formal thought disorder
Disorganized speech
Hayling sentence completion task
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Tue, 12 Jul 2016, 20:29:30 EST by Gail Robinson on behalf of School of Psychology