Pharmacology of the venom of Conus geographus

Endean R., Parish G. and Gyr P. (1974) Pharmacology of the venom of Conus geographus. Toxicon, 12 2: 131-138. doi:10.1016/0041-0101(74)90236-0


Author Endean R.
Parish G.
Gyr P.
Title Pharmacology of the venom of Conus geographus
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 1974-01-01
Sub-type Article (original research)
DOI 10.1016/0041-0101(74)90236-0
Volume 12
Issue 2
Start page 131
End page 138
Total pages 8
Subject 3005 Toxicology
Abstract Conus geographus venom has a direct action on vertebrate skeletal musculature. When exposed to venom extracts, all mammalian skeletal muscles tested became refractory to 30 V electrical stimulation. Mammalian smooth and cardiac musculature, barnacle musculature and 'slow' fibres of amphibian skeletal musculature were not obviously affected by venom extracts. Compound action potentials in amphibian sciatic nerve were not modified by prolonged exposure to venom extracts and conduction in the sciatic nerve did not appear to be affected. Transmembrane resting potentials in fibres from the frog sartorius were maintained essentially unchanged in the presence of the venom. Although it was not possible to induce action potentials in fibres from paralysed musculature, no evidence was obtained that sodium ion movements across membranes are affected by the venom. It was possible to overcome the block of direct electrical stimulation induced by the venom (25 μg per ml) by increasing voltage strength to 90-100 V or by using tetanic stimulation at 30 V. The material in the venom active against muscle was dialysable and stable to heating at 100°C.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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