Drugs and Depression

Whitlock F.A. and Evans L.E.J. (1978) Drugs and Depression. Drugs, 15 1: 53-71. doi:10.2165/00003495-197815010-00004

Author Whitlock F.A.
Evans L.E.J.
Title Drugs and Depression
Journal name Drugs   Check publisher's open access policy
ISSN 1179-1950
Publication date 1978-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2165/00003495-197815010-00004
Open Access Status Not yet assessed
Volume 15
Issue 1
Start page 53
End page 71
Total pages 19
Subject 2736 Pharmacology (medical)
2307 Health, Toxicology and Mutagenesis
3005 Toxicology
Abstract Moderate or severe depression is now one of the most common diseases of our time with a prevalence of nearly 3 %. It seems likely that this prevalence has increased as a result of the wider use of drugs which have an effect on the neurotransmitters. Changes in the levels of these neurotransmitters in the central nervous system are thought to he the biochemical basis for the development of at least some depressive illnesses. Drug-induced depressions are more likely to occur in those individuals who are genetically predisposed to depression or who have had a previous depressive illness. Other groups who are particularly susceptible to these effects are the elderly. Many groups of drugs have a primary or secondary action on the central nervous system neurotransmitter function. Some 200 drugs have been claimed to cause depression in certain patients, but only a relatively small number precipitate depressive symptoms with any frequency. Those most commonly implicated are the long-acting antipsychotics, barbiturates, ethanol, oral contraceptives and antihypertensive agents. It is important to remember that some drugs, such as reserpine, cause depression as a side-effect during their therapeutic use whereas others, such as fenfluramine, cause depression mainly when they are withdrawn too rapidly. In those patients presenting with depression, it is important to review the current drug therapy in order to assess the part played by these drugs in the development of the depression. Following this assessment, drug therapy should be adjusted appropriately. However, a distinction must be made between the symptoms of depression, those physiological changes which occur during treatment with a variety of drugs, and the patient’s reaction to the disease for which they are being treated.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import - Archived
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Citation counts: Scopus Citation Count Cited 31 times in Scopus Article | Citations
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Created: Tue, 12 Jul 2016, 13:37:31 EST by System User