An attempt to protect cats against infestation with Ctenocephalides felis felis using gut membrane antigens as a vaccine

Opdebeeck J.P. and Slacek B. (1993) An attempt to protect cats against infestation with Ctenocephalides felis felis using gut membrane antigens as a vaccine. International Journal for Parasitology, 23 8: 1063-1067. doi:10.1016/0020-7519(93)90127-K


Author Opdebeeck J.P.
Slacek B.
Title An attempt to protect cats against infestation with Ctenocephalides felis felis using gut membrane antigens as a vaccine
Journal name International Journal for Parasitology   Check publisher's open access policy
ISSN 0020-7519
Publication date 1993-01-01
Sub-type Article (original research)
DOI 10.1016/0020-7519(93)90127-K
Open Access Status
Volume 23
Issue 8
Start page 1063
End page 1067
Total pages 5
Subject 2405 Parasitology
2725 Infectious Diseases
Abstract Cats (n = 5) were vaccinated with membrane antigens extracted from the gut of unfed fleas (Ctenocephalides felis felis) together with Quil A and RIBI as adjuvants. Five unvaccinated cats were retained as controls. All the cats were infested on 6 separate occasions with fleas (46-250 per challenge). Protection was assessed from the number of fleas retrieved and the fecundity of the female fleas, measured as the number of developed oocytes contained in the reproductive tract. Cats injected with gut membrane antigens had significantly elevated levels of anti-flea antibodies in their sera, but they were neither protected significantly against infestation with fleas nor was the apparent fecundity of fleas which had fed on vaccinated cats decreased. The possible reason why gut membrane antigens failed to protect cats against fleas are discussed.
Keyword Cats
Ctenocephalides felis felis
flea vaccine
gut membrane
protection
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 12 Jul 2016, 12:45:14 EST by System User