Restricted activity of serum blocking factors related to a common tumour antigen in mice

Yong W.K. and Halliday W.J. (1983) Restricted activity of serum blocking factors related to a common tumour antigen in mice. Oncology (Switzerland), 40 3: 232-237. doi:10.1159/000225732


Author Yong W.K.
Halliday W.J.
Title Restricted activity of serum blocking factors related to a common tumour antigen in mice
Journal name Oncology (Switzerland)   Check publisher's open access policy
ISSN 1423-0232
Publication date 1983-01-01
Sub-type Article (original research)
DOI 10.1159/000225732
Volume 40
Issue 3
Start page 232
End page 237
Total pages 6
Subject 1306 Cancer Research
2730 Oncology
Abstract Mice of four different inbred strains (CBA, Balb/c, C57B1/6 and DBA/2), bearing different transplanted tumours (methylcholanthrene-induced sarcomas, BI6 melanoma and P-815 mastocytoma), were tested for cellular immune reactivity to the synthetic encephalitogcnic peptide of human myelin basic protein by the leucocyte adherence inhibition (LAI) assay. All exhibited reactivity at about the same optimal concentration of peptide. Normal mice of all strains and pregnant CBA mice were non-reactive. Blocking of LAI was detected with serum obtained 10 or more days after tumour transplantation. Sera from mice bearing different transplanted tumours abrogated the adherence-inhibitory effect of peptide on sensitized syngeneic peritoneal leucocytes. The blocking factors were cross-rcactive between different tumours only within the same mouse strain, indicating a requirement for genetic compatibility between donors of the reactive cells and the serum blocking factors.
Keyword Blocking factors
Common antigen
Ell-mediated immunity
Leucocyte adherence inhibition assay
Murine tumours
Strain restriction
Synthetic peptide
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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