Is AL-438 likely to have fewer side effects than the glucocorticoids?

Doggrell S. (2003) Is AL-438 likely to have fewer side effects than the glucocorticoids?. Expert Opinion on Investigational Drugs, 12 7: 1227-1229. doi:10.1517/eoid.12.7.1227.21767


Author Doggrell S.
Title Is AL-438 likely to have fewer side effects than the glucocorticoids?
Journal name Expert Opinion on Investigational Drugs   Check publisher's open access policy
ISSN 1354-3784
Publication date 2003-07-01
Sub-type Article (original research)
DOI 10.1517/eoid.12.7.1227.21767
Open Access Status Not yet assessed
Volume 12
Issue 7
Start page 1227
End page 1229
Total pages 3
Language eng
Subject 3004 Pharmacology
Abstract The glucocorticoids are effective anti-inflammatory agents but their use may be limited by systemic side effects. AL-438 and prednisolone inhibit binding to glucocorticoid and mineralcorticoid receptors with similar potency. In rat models of acute and chronic inflammation, AL-438 was effective but less potent than prednisolone. In fasted overnight rats, prednisolone was hyperglycaemic but AL-438 was not. Prednisolone also inhibited bone formation in rats, whereas AL-438 did not. The differing profile of AL-438 relative to prednisolone may be due to altered interactions between the receptor and selected co-activators. AL-438 may have lesser side effects than prednisolone.
Keyword AL-438
GR
Inflammation
Prednisolone
Side effects
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 12 Jul 2016, 12:21:53 EST by System User