Lantadene a toxicity in sheep. A model for cholestasis

Pass M.A., Seawright A.A., Lamberton J.A. and Heath T.J. (1979) Lantadene a toxicity in sheep. A model for cholestasis. Pathology, 11 1: 89-94. doi:10.3109/00313027909063543

Author Pass M.A.
Seawright A.A.
Lamberton J.A.
Heath T.J.
Title Lantadene a toxicity in sheep. A model for cholestasis
Journal name Pathology   Check publisher's open access policy
ISSN 0031-3025
Publication date 1979-01-01
Sub-type Article (original research)
DOI 10.3109/00313027909063543
Volume 11
Issue 1
Start page 89
End page 94
Total pages 6
Publisher Informa Healthcare
Subject 2734 Pathology and Forensic Medicine
Abstract Liver injury occurred after sheep were injected intravenously with the triterpene acid lantadene A, the toxic principle of the tropical plant Lantana camara. A single dose of 1-3 mg/kg of the compound caused mild hepatocellular injury characterized by transient rises in serum enzymes, with or without hyperbilirubinaemia. Higher doses resulted in hepatic necrosis. When low doses of the triterpene were given repeatedly over several days a cholestatic syndrome developed which appeared identical with that caused by consumption of the plant. This is a disease model which may be of value in experimental studies of intrahepatic cholestasis. This study provides evidence that lantadene A is hepatotoxic and does not require metabolism in the alimentary tract for toxicity in sheep.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Created: Tue, 12 Jul 2016, 12:15:05 EST by System User