Pathogenesis of meningo-encephalitis produced in calves by infectious bovine rhinotracheitis herpesvirus

Bagust T.J. and Clark L. (1972) Pathogenesis of meningo-encephalitis produced in calves by infectious bovine rhinotracheitis herpesvirus. Journal of Comparative Pathology, 82 4: . doi:10.1016/0021-9975(72)90036-9


Author Bagust T.J.
Clark L.
Title Pathogenesis of meningo-encephalitis produced in calves by infectious bovine rhinotracheitis herpesvirus
Journal name Journal of Comparative Pathology   Check publisher's open access policy
ISSN 0021-9975
Publication date 1972-01-01
Sub-type Article (original research)
DOI 10.1016/0021-9975(72)90036-9
Volume 82
Issue 4
Total pages 1
Subject 1103 Clinical Sciences
Abstract An investigation of the pathogenesis of meningo-encephalitis produced by the N569 strain of infectious bovine rhinotracheitis (IBR) herpesvirus, originally isolated from this disease in calves, showed that 4 to 5 days later intranasal instillation resulted in virus invading the central nervous system of 7 of 17 calves exposed. Virus appeared to pass to the brain from the nasal, tonsil and pharyngeal regions by the maxillary and mandibular branches of the trigeminal nerve. Entrance to the mid-brain was followed by generalization of virus infection throughout the brain and development of clinical meningo-encephalitis 10 to 11 days after infection. Epidural infection of 2 calves was followed by a fatal meningo-encephalitis in a calf 14 days after infection, but the route of invasion of the brain was not clear. Intravenous inoculation of 2 calves produced a viraemia of 2 to 3 days duration, the virus being associated mainly with leucocytes, but it did not result in meningo-encephalitis. Sporadic isolations of N569 virus in various organs provided indirect evidence of the occurrence of a transitory viraemia in 3 calves infected by the intranasal or epidural routes. Bovine nervous system tissues possessed receptors for IBR viruses isolated from rhinitis and vaginitis as well as for N569 virus.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 59 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 12 Jul 2016, 11:57:03 EST by System User