Vitamin D receptor expression in the embryonic rat brain

Burket, Rachel, McGrath, John and Eyles, Darryl (2003) Vitamin D receptor expression in the embryonic rat brain. Neuroscience Research Communications, 33 1: 63-71. doi:10.1002/nrc.10081

Author Burket, Rachel
McGrath, John
Eyles, Darryl
Title Vitamin D receptor expression in the embryonic rat brain
Journal name Neuroscience Research Communications   Check publisher's open access policy
ISSN 1520-6769
Publication date 2003-07-01
Year available 2003
Sub-type Article (original research)
DOI 10.1002/nrc.10081
Open Access Status
Volume 33
Issue 1
Start page 63
End page 71
Total pages 9
Editor W. H. Gispen
Place of publication Chichester
Publisher Wiley
Language eng
Subject C1
111714 Mental Health
110319 Psychiatry (incl. Psychotherapy)
Abstract We are interested in determining whether low maternal vitamin D-3 affects brain development in utero. Whilst the vitamin D receptor (VDR) has been identified in embryonic rat brains, the timing and magnitude of its expression across the brain remains unclear. In this study we have quantitated VDR expression during development as well correlated the timing of its appearance with two vital developmental events, apoptosis and mitosis. Brains from embryonic rats (embryonic days 15-23) were examined. We show that the well-described increase in apoptotic cells and decrease in mitotic cells during development correlates with the appearance of the VDR in brain tissue. Given that vitamin D-3 regulates mitosis and apoptosis in non-neuronal tissue we speculate that the timing of VDR expression in embryonic brain may directly or indirectly mediate features of neuronal apoptosis and mitosis.
Keyword Neurosciences
Vitamin D-3 Receptor Vdr
Brain Development
Nerve Growth-factor
Cells In-vitro
1,25-dihydroxyvitamin D-3
Retinoic Acid
Neurotrophic Factor
Analog Eb1089
Q-Index Code C1
Institutional Status UQ

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Created: Mon, 13 Aug 2007, 23:46:49 EST