The equine protease inhibitory system (Pi): Abnormal expressions of PiF, PiL, and PiS

Patterson S.D. and Bell K. (1986) The equine protease inhibitory system (Pi): Abnormal expressions of PiF, PiL, and PiS. Biochemical Genetics, 24 7-8: 529-543. doi:10.1007/BF00504333


Author Patterson S.D.
Bell K.
Title The equine protease inhibitory system (Pi): Abnormal expressions of PiF, PiL, and PiS
Journal name Biochemical Genetics   Check publisher's open access policy
ISSN 0006-2928
Publication date 1986-01-01
Sub-type Article (original research)
DOI 10.1007/BF00504333
Volume 24
Issue 7-8
Start page 529
End page 543
Total pages 15
Publisher Kluwer Academic Publishers-Plenum Publishers
Subject 1311 Genetics
1303 Specialist Studies in Education
Abstract Three cases of abnormal expression of the equine protease inhibitory alleles, Pi F, L, and S1, were observed following the examination of 30,000 plasma samples by one-dimensional acid (pH 4.6) polyacrylamide gel electrophoresis. Characterization of the abnormal proteins in terms of isoelectric point, molecular mass, inhibitory spectra, and sialic acid content was performed using one- and two-dimensional electrophoretic techniques. The Pi F and S1 abnormalities were postulated to be the result of amino acid substitutions causing alterations in the processing of the carbohydrate side chains. No explanation could be offered for the Pi L abnormality other than a charge shift mutation. Abnormal types, F*, L*, and S*1 behaved as alleles but the distribution of L* in offspring from one stallion (present in only 6 of 83 offspring) differed significantly from expectation.
Keyword α1-protease inhibitor
abnormal expression
altered carbohydrate processing
equine
mutation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 16 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 12 Jul 2016, 11:45:45 EST by System User