The immunological response of foals to Rhodococcus equi: A review

Woolcock J.B., Mutimer M.D. and Bowles P.M. (1987) The immunological response of foals to Rhodococcus equi: A review. Veterinary Microbiology, 14 3: 215-224. doi:10.1016/0378-1135(87)90108-8

Author Woolcock J.B.
Mutimer M.D.
Bowles P.M.
Title The immunological response of foals to Rhodococcus equi: A review
Journal name Veterinary Microbiology   Check publisher's open access policy
ISSN 0378-1135
Publication date 1987-01-01
Sub-type Article (original research)
DOI 10.1016/0378-1135(87)90108-8
Volume 14
Issue 3
Start page 215
End page 224
Total pages 10
Language eng
Subject 1103 Clinical Sciences
2404 Microbiology
3400 Veterinary
Abstract • Normal horses of all ages regularly show evidence of having responded immunologically to R. equi, thus adding serological support to epidemiological evidence that this organism is a normal intestinal inhabitant. More animals from "diseased" farms show a stronger antibody response when compared with foals from "healthy" farms. • Various serological tests have been used to detect evidence of infection and to release antibody level to severity of disease. Anti-R. equi IgG antibody levels, as measured by ELISA, are raised significantly during natural infection. Clinical severity of pneumonia can be correlated with lower specific antibody responses. Following experimental infection, immunological responses can be detected by complement fixation, indirect immunofluorescence, ELISA, lymphocyte blastogenesis and skin testing. • Very little work has been carried out to evaluate vaccines against R. equi infection and results have not been encouraging. Success in treatment has been reported following passive immunisation. Administration of immune leucocyte extracts has had no effect on morbidity or mortality rates. • The widespread distribution of this organism, together with the relative infrequency of disease caused by it, suggest that R. equi may initiate infection only in such circumstances as a very high infectious challenge, immunological immaturity or deficiency in the host and genetic predisposition.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
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Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 25 times in Scopus Article | Citations
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