The effect of immunosuppression on resistance to Rhodococcus equi in mice

Bowles P.M., Woolcock J.B. and Mutimer M.D. (1989) The effect of immunosuppression on resistance to Rhodococcus equi in mice. Veterinary Immunology and Immunopathology, 22 4: 369-378. doi:10.1016/0165-2427(89)90172-4

Author Bowles P.M.
Woolcock J.B.
Mutimer M.D.
Title The effect of immunosuppression on resistance to Rhodococcus equi in mice
Journal name Veterinary Immunology and Immunopathology   Check publisher's open access policy
ISSN 0165-2427
Publication date 1989-11-15
Sub-type Article (original research)
DOI 10.1016/0165-2427(89)90172-4
Volume 22
Issue 4
Start page 369
End page 378
Total pages 10
Language eng
Subject 1103 Clinical Sciences
2403 Immunology
3400 Veterinary
Abstract Rhodococcus equi, a natural pathogen of horses, produces lesions in mice following experimental infection. The effect of various immunosuppressing agents on the sequential development of these lesions has been assessed by measuring the growth of R. equi following intravenous or intranasal challenge and by histological examination. Cyclophosphamide treatment of mice, challenged intranasally, resulted in the development of lesions not unlike that seen in experimental and natural infection in foals. Cortisone acetate also impaired bacterial clearance from the lungs and affected the accumulation of mononuclear cells at infective foci. Most of the agents chosen to impair macrophage function failed to affect the resistance of mice to R. equi. Carbon, carrageenan and silica failed to alter significantly the growth kinetics of R. equi. Dextran sulphate depressed the rate of pulmonary clearance of organisms and affected the ability of animals to eliminate R. equi following rechallenge. Overall, these results support other evidence that cell mediated immunity is involved in host resistance to R. equi and that activated macrophages play a role in acquired immunity to this organism.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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