Premedication with oral midazolam in children - An assessment of psychomotor function, anxiolysis, sedation and pharmacokinetics

Jones R.D.M., Visram A.R., Kornberg J.P., Irwin M.G. and Gunawardene W.M.S. (1994) Premedication with oral midazolam in children - An assessment of psychomotor function, anxiolysis, sedation and pharmacokinetics. Anaesthesia and Intensive Care, 22 5: 539-544.

Author Jones R.D.M.
Visram A.R.
Kornberg J.P.
Irwin M.G.
Gunawardene W.M.S.
Title Premedication with oral midazolam in children - An assessment of psychomotor function, anxiolysis, sedation and pharmacokinetics
Journal name Anaesthesia and Intensive Care   Check publisher's open access policy
ISSN 0310-057X
Publication date 1994-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 22
Issue 5
Start page 539
End page 544
Total pages 6
Language eng
Subject 2703 Anesthesiology and Pain Medicine
Abstract We studied 30 children, aged 4 to 12 years, undergoing elective circumcision, premedicated with midazolam 0.5 mg.kg and atropine 0.02 mg.kg by mouth. A modified postbox test and the coding component of the Wechsler intelligence scale (WISC-R) was used to assess the preoperative effect of premedication on psychomotor function. Mood and sedation were also scored and related to serum midazolam concentrations. The children showed a significant decline in psychomotor performance 30 and 60 minutes after premedication when compared with their best unmedicated performance recorded the previous evening. This decline in psychomotor performance was only weakly associated with serum midazolam concentrations (r = 0.1). The postbox toy ratio is a suitable measurement of psychomotor performance in children because of its simplicity and ease of use in the clinical environment, although it may suffer the 'test-retest' limitations of similar types of assessment. The sedative and anxiolytic effects of midazolam provide a quiet environment for a smooth induction of anaesthesia.
Keyword Midazolam
Paediatric anaesthesia
Premedication
Psychomotor assessment
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 12 Jul 2016, 11:11:22 EST by System User