The effects on some receptors of guinea pig trachea of a series of sympathomimetic amines

Chahl L.A. and O'Donnell S.R. (1971) The effects on some receptors of guinea pig trachea of a series of sympathomimetic amines. European Journal of Pharmacology, 16 2: 201-208. doi:10.1016/0014-2999(71)90011-2


Author Chahl L.A.
O'Donnell S.R.
Title The effects on some receptors of guinea pig trachea of a series of sympathomimetic amines
Journal name European Journal of Pharmacology   Check publisher's open access policy
ISSN 0014-2999
Publication date 1971-01-01
Sub-type Article (original research)
DOI 10.1016/0014-2999(71)90011-2
Volume 16
Issue 2
Start page 201
End page 208
Total pages 8
Subject 2804 Cellular and Molecular Neuroscience
3004 Pharmacology
Abstract A series of 12 sympathomimetic amines was studied on the guinea pid tracheal chain preparation. All of the compounds, except methoxamine, produced some relaxation of the normal tracheal chain preparation and this relaxation was blocked by propranolol. For those compounds which had no hydroxyl groups in their structure this relaxation was due to release of noradrenaline since it was absent on preparations from reserpinized animals. Compounds with two or three hydroxyl groups had potent activity directly on β-receptors. As the concentration of amine was increased contractions of the trachea were observed with all of the compounds except ethylnoradrenaline, corbasil, nylidrin and isoxsuprine. These contractions were antagonized by α-receptor blocking drugs. Another type of relaxation which was not blocked by propranolol was observed with most of the drugs at still higher concentrations. There was considerable overlap in the concentration ranges producing these three types of response. Ephedrine, methoxamine and methoxyphenamine were found to possess β-receptor blocking activity.
Keyword Guinea pig tracheal chain
α-Adrenoreceptor stimulation
β-Adrenoreceptor stimulation Sympathomimetic amines
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 12 Jul 2016, 10:56:32 EST by System User