Separation of two myotoxins from nematocysts of the box jellyfish (Chironex fleckeri)

Endean R. (1987) Separation of two myotoxins from nematocysts of the box jellyfish (Chironex fleckeri). Toxicon, 25 5: 483-492. doi:10.1016/0041-0101(87)90284-4


Author Endean R.
Title Separation of two myotoxins from nematocysts of the box jellyfish (Chironex fleckeri)
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 1987-01-01
Sub-type Article (original research)
DOI 10.1016/0041-0101(87)90284-4
Volume 25
Issue 5
Start page 483
End page 492
Total pages 10
Subject 3005 Toxicology
Abstract Two myotoxins, both lethal to mice by i.v. injection, were obtained by chromatography on Sephadex G-200 of material released from isolated microbasic mastigophores of C. fleckeri. Both toxins elicit contractures of skeletal (diaphragm) musculature of the rat and of smooth (ileum and vas deferens) and atrial musculature of the guinea-pig, although consistent differences in the parameters of the contractures of each muscle type elicited by the two toxins are shown. Moreover, one toxin, with a molecular weight of approximately 150, 000, also elicits activity on crustacean (barnacle) musculature, whilst the other toxin, with a molecular weight of approximately 600, 000, elicits no activity in barnacle musculature at the concentrations tested. The toxins are labile when released from nematocysts myotoxic activity within 3 days at 5°C. They can also be isolated chromatographically from crude extracts of the contents of mixed nematocyts of C. fleckeri. They are considered to be the principal toxins injected by C. fleckeri during nematocyst discharge and appeared to be different from the C. fleckeri toxins described by other workers.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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