The effects of 6-hydroxydopamine and guanethidine on peripheral adrenergic nerves in the guinea pig

O'Donnell S.R. and Saar N. (1974) The effects of 6-hydroxydopamine and guanethidine on peripheral adrenergic nerves in the guinea pig. European Journal of Pharmacology, 28 2: 251-256. doi:10.1016/0014-2999(74)90277-5


Author O'Donnell S.R.
Saar N.
Title The effects of 6-hydroxydopamine and guanethidine on peripheral adrenergic nerves in the guinea pig
Journal name European Journal of Pharmacology   Check publisher's open access policy
ISSN 0014-2999
Publication date 1974-01-01
Sub-type Article (original research)
DOI 10.1016/0014-2999(74)90277-5
Volume 28
Issue 2
Start page 251
End page 256
Total pages 6
Subject 2804 Cellular and Molecular Neuroscience
3004 Pharmacology
Abstract Chemical sympathectomy was achieved in guinea pig trachea 24 hr after a single dose of 50 mg/kg (i.v. or i.p.) 6-hydroxydopamine (6-OHDA). This was shown by (a) the dissapearance of fluorescent nerve terminals (b) decreased uptake-with-retention of radioactivity following incubation in (-)-3H-noradrenaline (50 nM) and (c) the supersensitive response of the isolated tracheal chain preparation to noradrenaline. The susceptibility of the adrenergic nerve terminals in the lung of 6-OHDA resembled that of trachea, in that complete dissapearance of fluorescent nerve terminals was achieved with the above doses, whereas doses higher than 100 mg/kg were required to produce this in heart and iris. Chronic treatment of guinea pigs with guanethidine (25 or 30 mg/kg daily by i.p. injection for up to 6 weeks) did not produce destruction of adrenergic nerves in peripheral tissues.
Keyword 6-Hydroxydopamine
Fluorescence histochemistry Chemical sympathetomy
Guanethidine
Guinea pig
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 12 Jul 2016, 10:33:01 EST by System User