The binding of ethyl carbamate to liver DNA in gonadectomised mice

Lawson T.A. (1974) The binding of ethyl carbamate to liver DNA in gonadectomised mice. Biochemical and Biophysical Research Communications, 60 1: 364-370. doi:10.1016/0006-291X(74)90213-7


Author Lawson T.A.
Title The binding of ethyl carbamate to liver DNA in gonadectomised mice
Journal name Biochemical and Biophysical Research Communications   Check publisher's open access policy
ISSN 1090-2104
Publication date 1974-09-09
Sub-type Article (original research)
DOI 10.1016/0006-291X(74)90213-7
Open Access Status Not yet assessed
Volume 60
Issue 1
Start page 364
End page 370
Total pages 7
Subject 1303 Specialist Studies in Education
1304 Biophysics
1312 Molecular Biology
Abstract Castration, with or without subsequent hormone administration resulted in different levels of binding of a metabolite of ethyl carbamate to mouse liver DNA. In ovariectomised and ovariectomy plus testosterone-treated females, the binding persisted for longer than in intact and ovariectomy plus estradiol-treated females, although the maximum levels of binding were similar in all four groups. In males, orchidectomy dramatically lowered the level of binding compared with that in intact males. Twelve hours after dosing, the levels of binding were 276 and 9.8 nanomoles g. DNA-1 respectively in the two groups. Estradiol treatment did not restore the level of binding whereas testosterone treatment did.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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