Pharmacokinetics of alcuronium in elderly patients undergoing total hip replacement or aortic reconstructive surgery

Stephens I.D., Ho P.C., Holloway A.M., Bourne D.W. and Triggs E.J. (1984) Pharmacokinetics of alcuronium in elderly patients undergoing total hip replacement or aortic reconstructive surgery. British Journal of Anaesthesia, 56 5: 465-471.

Author Stephens I.D.
Ho P.C.
Holloway A.M.
Bourne D.W.
Triggs E.J.
Title Pharmacokinetics of alcuronium in elderly patients undergoing total hip replacement or aortic reconstructive surgery
Journal name British Journal of Anaesthesia   Check publisher's open access policy
ISSN 0007-0912
Publication date 1984-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 56
Issue 5
Start page 465
End page 471
Total pages 7
Language eng
Subject 2703 Anesthesiology and Pain Medicine
1804 Statistics, Probability and Uncertainty
2604 Applied Mathematics
2600 Mathematics
2613 Statistics and Probability
1101 Medical Biochemistry and Metabolomics
Abstract The pharmacokinetic behaviour of alcuronium was studied in three patients undergoing resection of an aortic aneurysm, and in another two patients undergoing total hip replacement (group I). A control group of five elderly patients undergoing relatively minor surgery was included (group II). In group I patients, the values of the pharmacokinetic parameters such as plasma clearance, elimination half-life and the apparent volume of distribution of the drug were found to be comparable to those obtained in normal young patients in previous studies. The group II patients, however, were found to have a prolonged elimination half-life as a result of reduced plasma clearance, possibly an age-related effect. The differences between those two groups of patients may be explained by the differences in the extent of haemorrhage and fluid replacement or changes in blood circulation, or both. However, alcuronium must still be used cautiously in both groups of patients, especially in the light of a recent finding that patients undergoing aortic reconstructive surgery have a high frequency of functional renal failure after operation.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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