Spiroacetals of marine origin

Jacobs M.F. and Kitching W. (1998) Spiroacetals of marine origin. Current Organic Chemistry, 2 4: 395-436.

Author Jacobs M.F.
Kitching W.
Title Spiroacetals of marine origin
Journal name Current Organic Chemistry   Check publisher's open access policy
ISSN 1385-2728
Publication date 1998-01-01
Sub-type Critical review of research, literature review, critical commentary
Open Access Status Not yet assessed
Volume 2
Issue 4
Start page 395
End page 436
Total pages 42
Language eng
Subject 1605 Policy and Administration
Abstract The structures, origins and biological activities of marine-derived compounds incorporating a spiroacetal sub-structure are reviewed. Such compounds include okadaic acid, the ciguatoxins, the halichondrins, the spongistatins, the cephalostatins, the calyculins and the aplysiatoxins, the structures of which illustrate the highly varied and often complex molecular design produced by marine biota. Synthetic approaches to a number of these classes are discussed in detail, with particular attention given to the synthesis of calyculin A by the research groups of Evans, Masamune and Shioiri. These synthetic endeavours emphasise the undiminished influence of natural product chemistry on the nature and direction of organic chemistry. Furthermore, they demonstrate that despite the emergence of powerful methods for molecular structure determination, partial or complete stereocontrolled syntheses are still required to validate stereochemical detail in large, highly functionalised molecules. Finally, these discussions confirm the versatility of modern asymmetric synthetic methodology in tactical molecular construction.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import - Archived
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Citation counts: Scopus Citation Count Cited 65 times in Scopus Article | Citations
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Created: Sat, 09 Jul 2016, 15:46:25 EST by System User