Genetically altered herpesviruses as vaccines

Young P.L. and Smith G.A. (1995) Genetically altered herpesviruses as vaccines. Veterinary Microbiology, 46 1-3: 175-179. doi:10.1016/0378-1135(95)00081-K

Author Young P.L.
Smith G.A.
Title Genetically altered herpesviruses as vaccines
Journal name Veterinary Microbiology   Check publisher's open access policy
ISSN 0378-1135
Publication date 1995-01-01
Sub-type Article (original research)
DOI 10.1016/0378-1135(95)00081-K
Volume 46
Issue 1-3
Start page 175
End page 179
Total pages 5
Subject 2404 Microbiology
3400 Veterinary
1103 Clinical Sciences
Abstract Herpesviruses are a common and important cause of disease in most domestic animals. While many virus diseases have been successfully controlled by conventional vaccines, genetically modified vaccines offer distinct advantages. They are less virulent, less likely to result in latency and they include genotypic and phenotypic markers which allow differentiation of vaccine virus from wildtype virus and serological differentiation of vaccinated animals from infected animals. These benefits are particularly useful in eradication campaigns for herpesvirus diseases such as Aujeszky's disease and infectious bovine rhinotracheitis. Neither conventional nor genetically modified vaccines prevent super-infection. This is a major problem for diseases such as Marek's disease where virulent virus continues to be excreted from vaccinated animals, thus contaminating the environment and making control more difficult. To prevent infection, new strategies will need to be developed such as transgenic animals which are innately resistant.
Keyword Herpesvirus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
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Citation counts: Scopus Citation Count Cited 7 times in Scopus Article | Citations
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Created: Sat, 09 Jul 2016, 15:42:06 EST by System User