Lipofuscin as a record of ‘rate of living’ in an aquatic poikilotherm

Sheehy M.R.J., Greenwood J.G. and Fielder D.R. (1995) Lipofuscin as a record of ‘rate of living’ in an aquatic poikilotherm. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 50A 6: B327-B336. doi:10.1093/gerona/50A.6.B327


Author Sheehy M.R.J.
Greenwood J.G.
Fielder D.R.
Title Lipofuscin as a record of ‘rate of living’ in an aquatic poikilotherm
Journal name Journals of Gerontology - Series A Biological Sciences and Medical Sciences   Check publisher's open access policy
ISSN 1758-535X
Publication date 1995-01-01
Sub-type Article (original research)
DOI 10.1093/gerona/50A.6.B327
Volume 50A
Issue 6
Start page B327
End page B336
Total pages 1
Subject 1302 Curriculum and Pedagogy
2717 Geriatrics and Gerontology
Abstract As an integral of oxidative metabolism and physiological age index, lipofuscin accumulation was used to evaluate assumptions underlying previous rejection of the rate of living theory of aging. Lipofuscin in the olfactory lobe cell mass of crayfish, Cherax quadricarinatus, was measured throughout life under a wide range of temperature regimes, using image analysis of fluorescence micrographs of brain sections. The relationship between temperature, chronological age, and rate of living, as indicated by lipofuscin accumulation rate, had a complex nonlinear threedimensional structure, suggesting a thermal optimum, thermal mid-range metabolic compensation, and ageassociated variation. The particular experimental window through which this response surface is viewed will have a profound effect on the outcome of life span experiments such as those previously used to test the rate of living theory. The results of this study further challenge assumptions leading to previous rejection of this theory.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
 
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