24-Hour plasma etoposide profile after oral and intravenous administration in children

Pinkerton, CR, Dick, G and Aherne, GW (1993) 24-Hour plasma etoposide profile after oral and intravenous administration in children. European Journal of Cancer, 29 10: 1479-1481. doi:10.1016/0959-8049(93)90025-B


Author Pinkerton, CR
Dick, G
Aherne, GW
Title 24-Hour plasma etoposide profile after oral and intravenous administration in children
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
Publication date 1993-01-01
Sub-type Article (original research)
DOI 10.1016/0959-8049(93)90025-B
Volume 29
Issue 10
Start page 1479
End page 1481
Total pages 3
Language eng
Subject 1306 Cancer Research
2720 Hematology
2730 Oncology
Abstract Pharmacokinetic profiles of oral and intravenous etoposide have been compared in 9 children receiving the drug either as a single agent or in combination chemotherapy. The plasma etoposide levels were estimated using a competitive coated antigen ELISA technique. The median bioavailability was 48% and beyond 30 min after either oral or intravenous injection there was little difference in the plasma profile. The duration of plasma concentrations above 1, 5 and 10 μg/ml following either route were compared. It is concluded that unless the height of initial peak concentration is of therapeutic value the oral route should be comparable in children provided that twice the intravenous dose is administered. The short elimination half-life results in low plasma levels beyond 12 h and suggests that a twice daily regimen may be preferable.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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