Pilot study of a rapid etoposide-cisplatin regimen in paediatric soft tissue sarcomas

Phillips, MB and Pinkerton, CR (1992) Pilot study of a rapid etoposide-cisplatin regimen in paediatric soft tissue sarcomas. European Journal of Cancer, 28 2-3: 399-403. doi:10.1016/S0959-8049(05)80062-0


Author Phillips, MB
Pinkerton, CR
Title Pilot study of a rapid etoposide-cisplatin regimen in paediatric soft tissue sarcomas
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
Publication date 1992-01-01
Year available 1992
Sub-type Article (original research)
DOI 10.1016/S0959-8049(05)80062-0
Open Access Status Not yet assessed
Volume 28
Issue 2-3
Start page 399
End page 403
Total pages 5
Publisher PERGAMON-ELSEVIER SCIENCE LTD
Language eng
Subject 1306 Cancer Research
2730 Oncology
Abstract 10 patients with refractory or relapsed soft tissue sarcoma were treated with weekly etoposide (150 mg/m2 on days 1, 2 and 3) and cisplatin (60 mg/m2 on day 2). Toxicity was mainly myelosuppression which resulted in deviation from planned weekly chemotherapy scheduling. With this rapid dose-delivery schedule the tolerated median dose intensities were 161 mg/m2 per week for etoposide and 49 mg/m2 per week for cisplatin. In 9 evaluable patients there were 7 responses, 2 complete and 5 partial, giving a response rate of 78% (confidence interval 51-100%). The combination of etoposide and cisplatin in this schedule produced a higher response rate than reported with previous schedules and is worthy of further evaluation.
Keyword Oncology
Oncology
ONCOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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