A randomised study of prophylactic G-CSF following MRC UKALL XI intensification regimen in childhood ALL and T-NHL

Little, M. A., Morland, B., Chisholm, J., Hole, A., Shankar, A., Devine, T., Easlea, D., Meyer, L. C. and Pinkerton, C. R. (2002) A randomised study of prophylactic G-CSF following MRC UKALL XI intensification regimen in childhood ALL and T-NHL. Medical and Pediatric Oncology, 38 2: 98-103. doi:10.1002/mpo.1279


Author Little, M. A.
Morland, B.
Chisholm, J.
Hole, A.
Shankar, A.
Devine, T.
Easlea, D.
Meyer, L. C.
Pinkerton, C. R.
Title A randomised study of prophylactic G-CSF following MRC UKALL XI intensification regimen in childhood ALL and T-NHL
Journal name Medical and Pediatric Oncology   Check publisher's open access policy
ISSN 0098-1532
1545-5017
1545-5009
Publication date 2002-02-01
Year available 2002
Sub-type Article (original research)
DOI 10.1002/mpo.1279
Open Access Status Not yet assessed
Volume 38
Issue 2
Start page 98
End page 103
Total pages 6
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Backgound: Despite the current widespread use of prophylactic G-CSF in children with solid tumours and leukaemia, its effectiveness has not been clearly demonstrated. This randomised study evaluates the role of G-CSF given after a 5-day intensification block in children with acute lymphoblastic leukaemia (ALL).

Procedure: Forty-six children with ALL or T-Cell non-Hodgkins lymphoma (NHL) treated on MRC ALL 97, UKALL XI or UKCCSG 9504 NHL protocols were randomised to receive granulocyte colony-stimulating factor following either the first or the second block of intensive chemotherapy in a cross-over study to determine if the prophylactic administration of G-CSF could reduce the rate of readmission to hospital for management of febrile neutropenia.

Results: There was a statistically significant difference in the rate of hospital admission in the group receiving prophylaxis, with 34 of 46 being admitted, compared to 42 of 46 patients in the control arm (74 vs. 91%; P = 0.0386). There were no differences found in duration of hospital admission, haematological toxicity, neutrophil recovery or duration of supportive care between the two groups. There was no demonstrable cost benefit derived from the prophylactic administration of G-CSF.

Conclusions: This study shows that the prophylactic administration of G-CSF following intensification chemotherapy for childhood ALL and T-NHL produces a significant reduction in the rate of readmission to hospital for the management of febrile neutropenia.
Keyword Acute lymphoblastic leukaemia
Childhood cancer
Febrile neutropenia
G-CSF
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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