Phase II study of rapid-scheduled etoposide in paediatric soft tissue sarcomas

Phillips, MB, Flamant, F, Sommeletolive, D and Pinkerton, CR (1995) Phase II study of rapid-scheduled etoposide in paediatric soft tissue sarcomas. European Journal of Cancer, 31 5: 782-784. doi:10.1016/0959-8049(95)00092-W


Author Phillips, MB
Flamant, F
Sommeletolive, D
Pinkerton, CR
Title Phase II study of rapid-scheduled etoposide in paediatric soft tissue sarcomas
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
Publication date 1995-01-01
Year available 1995
Sub-type Article (original research)
DOI 10.1016/0959-8049(95)00092-W
Open Access Status Not Open Access
Volume 31
Issue 5
Start page 782
End page 784
Total pages 3
Publisher PERGAMON-ELSEVIER SCIENCE LTD
Language eng
Subject 1306 Cancer Research
2730 Oncology
2720 Hematology
Abstract Twenty three patients with paediatric soft tissue sarcomas who had relapsed or refractory disease were treated with a rapid schedule of intravenous etoposide (100 mg/m2 daily on three consecutive days, weekly over 3 weeks). The regimen was well tolerated with predictable myelotoxicity. In 19 patients with rhabdomyosarcoma, there was a response rate of 42%. This appears to be better than previously reported with conventional three weekly schedules. These data indicate that for rhabdomyosarcoma, as for some other tumours, a divided dose regimen may be the optimal schedule and is worthy of further evaluation.
Keyword childhood tumours
dose intensity
etoposide
rapid-schedule
rhabdomyosarcoma
sarcoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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