A randomized comparison of intravenously administered granisetron versus chlorpromazine plus dexamethasone in the prevention of ifosfamide-induced emesis in children

Hahlen, K, Quintana, E, Pinkerton, CR and Cedar, E (1995) A randomized comparison of intravenously administered granisetron versus chlorpromazine plus dexamethasone in the prevention of ifosfamide-induced emesis in children. The Journal of Pediatrics, 126 2: 309-313. doi:10.1016/S0022-3476(95)70568-6


Author Hahlen, K
Quintana, E
Pinkerton, CR
Cedar, E
Title A randomized comparison of intravenously administered granisetron versus chlorpromazine plus dexamethasone in the prevention of ifosfamide-induced emesis in children
Journal name The Journal of Pediatrics   Check publisher's open access policy
ISSN 0022-3476
Publication date 1995-01-01
Sub-type Article (original research)
DOI 10.1016/S0022-3476(95)70568-6
Volume 126
Issue 2
Start page 309
End page 313
Total pages 5
Language eng
Subject 2735 Pediatrics, Perinatology, and Child Health
Abstract Purpose: To compare the efficacy and safety of intravenously administered granisetron with those of chlorpromazine plus dexamethasone in the prevention of ifosmamide-induced emesis in children with malignant disease. Patients and methods: Eighty-eight children, aged 2 to 17 years, were scheduled for ifosfamide therapy (≥3 gm/m2) for 2 or 3 consecutive days. On each day, children received granisetron, 20 μg/kg intravenously, before ifosfamide therapy, plus up to two more doses within 24 hours if required, or chlorpromazine, 0.3 to 0.5 mg/kg intravenously, every 4 to 6 hours, plus dexamethasone, 2 mg/m2 intravenously every 8 hours. Results : During the initial 24 hours, significantly fewer episodes of vomiting were recorded after granisetron administration (median number, 1.5 vs 7.0; p = 0.001), and the percentages of children having no more than one vomiting episode (51% granisetron vs 21% chlorpromazine-dexamethasone) and no worse than mild nausea (67% granisetron vs 38% chlorpromazine-dexamethasone) were lower after granisetron therapy (p <0.01). Fewer children had sedation with gran-isetron (2 vs 19; p <0.001); there were no extrapyramidal reactions during gran-isetron therapy compared with two during control therapy. Conclusion: Granisetron was superior to chlorpromazine-dexamethasone antiemetic therapy for children receiving ifosfamide therapy and deserves further study during other chemotherapy regimens. (J PEDIATR 1995;126:309-13).
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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