Outcome of children with resistant and relapsed hodgkin’s disease

James, ND, Kingston, JE, Plowman, PN, Meller, S, Pinkerton, R, Barrett, A, Sandland, R, McElwain, TJ and Malpas, JS (1992) Outcome of children with resistant and relapsed hodgkin’s disease. British Journal of Cancer, 66 6: 1155-1158. doi:10.1038/bjc.1992.426

Author James, ND
Kingston, JE
Plowman, PN
Meller, S
Pinkerton, R
Barrett, A
Sandland, R
McElwain, TJ
Malpas, JS
Title Outcome of children with resistant and relapsed hodgkin’s disease
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 1532-1827
Publication date 1992-01-01
Year available 1992
Sub-type Article (original research)
DOI 10.1038/bjc.1992.426
Open Access Status Not yet assessed
Volume 66
Issue 6
Start page 1155
End page 1158
Total pages 4
Language eng
Subject 1306 Cancer Research
2730 Oncology
Abstract During the period 1974-89, 169 children with Hodgkin’s disease were treated in the Paediatric Oncology Units of the Royal Marsden and St Bartholomew’s Hospitals. The overall actuarial survival for the whole group was 81% at 10 years. Thirty-five of the 169 children either did not achieve a complete remission or subsequently relapsed. The estimated actuarial survival from initial relapse or failure of primary treatment was 60% at 5 years and 45% at 10 years. Over half of the patients requiring salvage therapy had declared themselves within 2 years and only 3 relapses occurred more than 3 years from diagnosis. Very few patients remain disease free long term after failure of primary and initial salvage therapy. Patients relapsing within a year of diagnosis or not achieving a complete response to primary therapy and those with disseminated relapse had a poor response to salvage therapy. A significant subgroup of patients had prolonged survival despite multiple relapses. Neither initial histology nor stage affected survival from relapse although numbers in each subgroup were small.
Keyword Oncology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
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