21-day schedule oral etoposide in children- a feasibility study

Davidson, A, Lewis, I, Pearson, Adj, Stevens, McG and Pinkerton, CR (1993) 21-day schedule oral etoposide in children- a feasibility study. European Journal of Cancer, 29 16: 2223-2225. doi:10.1016/0959-8049(93)90210-7

Author Davidson, A
Lewis, I
Pearson, Adj
Stevens, McG
Pinkerton, CR
Title 21-day schedule oral etoposide in children- a feasibility study
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
Publication date 1993-01-01
Year available 1993
Sub-type Article (original research)
DOI 10.1016/0959-8049(93)90210-7
Open Access Status Not yet assessed
Volume 29
Issue 16
Start page 2223
End page 2225
Total pages 3
Language eng
Subject 1306 Cancer Research
2720 Hematology
2730 Oncology
Abstract To determine the feasibility and toxicity of prolonged oral etoposide in children, 22 patients with relapsed or refractory disease were commenced on etoposide 50-100 mgs/m2 per day for 21 days. A second course was administered after full blood count recovery, followed by disease reassessment. In total, 72 courses were evaluable for toxicity, with 10% of completed courses complicated by febrile neutropenia. 15 patients were evaluable for response, with 1 partial response, 10 stable disease and 4 progressive disease. This schedule was well tolerated with acceptable toxicity when doses of less than 80 mg/m2/day were administered and warrants further evaluation.
Keyword Oncology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
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