Polyceraty (multi-horns) in Damara sheep maps to ovine chromosome 2

Greyvenstein, O. F. C., Reich, C. M., van Marle-Koster, E., Riley, D. G. and Hayes, B. J. (2016) Polyceraty (multi-horns) in Damara sheep maps to ovine chromosome 2. Animal Genetics, 47 2: 263-266. doi:10.1111/age.12411

Author Greyvenstein, O. F. C.
Reich, C. M.
van Marle-Koster, E.
Riley, D. G.
Hayes, B. J.
Title Polyceraty (multi-horns) in Damara sheep maps to ovine chromosome 2
Journal name Animal Genetics   Check publisher's open access policy
ISSN 1365-2052
Publication date 2016-04-01
Year available 2016
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1111/age.12411
Open Access Status Not Open Access
Volume 47
Issue 2
Start page 263
End page 266
Total pages 4
Place of publication Chichester, West Sussex United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Polyceraty (presence of multiple horns) is rare in modern day ungulates. Although not found in wild sheep, polyceraty does occur in a small number of domestic sheep breeds covering a wide geographical region. Damara are fat-tailed hair sheep, from the south-western region of Africa, which display polyceraty, with horn number ranging from zero to four. We conducted a genome-wide association study for horn number with 43 Damara genotyped with 606 006 SNP markers. The analysis revealed a region with multiple significant SNPs on ovine chromosome 2, in a location different from the mutation for polled in sheep on chromosome 10. The causal mutation for polyceraty was not identified; however, the region associated with polyceraty spans nine HOXD genes, which are critical in embryonic development of appendages. Mutations in HOXD genes are implicated in polydactly phenotypes in mice and humans. There was no evidence for epistatic interactions contributing to polyceraty. This is the first report on the genetic mechanisms underlying polyceraty in the under-studied Damara.
Keyword GWAS
Multiple horns
Ovine Infinium
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collections: HERDC Pre-Audit
Queensland Alliance for Agriculture and Food Innovation
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 07 Jul 2016, 21:31:46 EST by Anthony Yeates on behalf of Centre for Animal Science