Predicting resistance of sheep to Haemonchus contortus infections

Riffkin G.G. and Dobson C. (1979) Predicting resistance of sheep to Haemonchus contortus infections. Veterinary Parasitology, 5 4: 365-378. doi:10.1016/0304-4017(79)90027-X

Author Riffkin G.G.
Dobson C.
Title Predicting resistance of sheep to Haemonchus contortus infections
Journal name Veterinary Parasitology   Check publisher's open access policy
ISSN 0304-4017
Publication date 1979-01-01
Sub-type Article (original research)
DOI 10.1016/0304-4017(79)90027-X
Open Access Status Not yet assessed
Volume 5
Issue 4
Start page 365
End page 378
Total pages 14
Language eng
Subject 1103 Clinical Sciences
2405 Parasitology
3400 Veterinary
Abstract In vitro cultures of lymphocytes from worm-free sheep responded to larval and adult H. contortus antigens by undergoing blast transformation. The level of response varied considerably between animals but was heritable and positively correlated with resistance to subsequent primary, secondary and trickle infection by the parasite, but not with age of the sheep older than 5 months. Lymphocyte responses to phytohaemagglutinin and H. contortus antigens were not present at birth in lambs but developed during the first 5 months in the absence of infection. The proportion of the infecting dose of larvae which was inhibited at the early fourth stage correlated with age of the sheep and with the increase in lymphocyte response to H. contortus antigens during primary infections with H. contortus. Sheep which were most susceptible to infection had the lowest lymphocyte responses to H. contortus antigens but had the highest rate of weight gain during infection. It is suggested that man has selected the most productive animals at the expense of resistance to H. contortus. The definition of genetically controlled markers on lymphocytes is seen as a means by which disease resistant strains of animals may be selected.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Citation counts: TR Web of Science Citation Count  Cited 40 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 41 times in Scopus Article | Citations
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