The effect of ultrasound on experimental oedema in rats

Fyfe M.C. and Chahl L.A. (1980) The effect of ultrasound on experimental oedema in rats. Ultrasound in Medicine and Biology, 6 2: 107-111. doi:10.1016/0301-5629(80)90038-1

Author Fyfe M.C.
Chahl L.A.
Title The effect of ultrasound on experimental oedema in rats
Journal name Ultrasound in Medicine and Biology   Check publisher's open access policy
ISSN 0301-5629
Publication date 1980-01-01
Sub-type Article (original research)
DOI 10.1016/0301-5629(80)90038-1
Open Access Status Not yet assessed
Volume 6
Issue 2
Start page 107
End page 111
Total pages 5
Language eng
Subject 2741 Radiology Nuclear Medicine and imaging
Abstract The effect of ultrasound at a space-averaged intensity of 0.5 W/cm2:administered for 2-5 min at frequencies of 2.9, 1.5 and 0.79 MHz and mark-space ratios of 1:4(2 ms:8 ms) and 1:1(2 ms:2 ms) was investigated on the acute oedema response of rats to intracutaneous injection of silver nitrate. Rats. anaesthetized with ether were given Evans blue intravenously and two intracutaneous injections of silver nitrate (2 × 10-6 mol) into the abdominal skin. Insonation of one skin site and mock-insonation of the other was performed immediately after the injections. Rats were killed 30 min after the injections and oedema response measured by the amount of dye leakage expressed as absorbance. Significant reduction of dye leakage occurred with treatment of injection sites with ultrasound at 0.79 MHz frequency and durations of application of 2 and 4 min for both mark-space ratios,but not with the other frequencies and durations tested. Further studies are necessary to determine the relevance of this finding to the clinical efficacy of ultrasound in certain inflammatory conditions.
Keyword Inflammation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Created: Tue, 05 Jul 2016, 15:36:50 EST by System User