Toxicity of reduced lantadene A (22β-angeloyloxyoleanolic acid) in the rat

Pass M.A., Findlay L., Pugh M.W. and Seawright A.A. (1979) Toxicity of reduced lantadene A (22β-angeloyloxyoleanolic acid) in the rat. Toxicology and Applied Pharmacology, 51 3: 515-521. doi:10.1016/0041-008X(79)90376-4

Author Pass M.A.
Findlay L.
Pugh M.W.
Seawright A.A.
Title Toxicity of reduced lantadene A (22β-angeloyloxyoleanolic acid) in the rat
Journal name Toxicology and Applied Pharmacology   Check publisher's open access policy
ISSN 1096-0333
Publication date 1979-01-01
Sub-type Article (original research)
DOI 10.1016/0041-008X(79)90376-4
Volume 51
Issue 3
Start page 515
End page 521
Total pages 7
Language eng
Subject 3004 Pharmacology
3005 Toxicology
Abstract Reduced lantadene A was administered as a single oral dose to Wistar rats. The intoxication was characterized by jaundice, anorexia, constipation, polyuria, polydipsia, and accumulation of predominantly conjugated bilirubin in the serum. The liver lesion was consistent with intrahepatic cholestasis and was characterized by swelling of hepatocytes, individual cell necrosis, and biliary ductular hyperplasia. Zonal changes in the liver acini were not evident. Degeneration and necrosis of the proximal tubules in the kidneys were detected. Based on these criteria the ED50 for female rats was estimated to be 15 mg/kg but doses up to 200 mg/kg failed to intoxicate male animals. The clinical syndrome and pathological changes in the liver were similar to those seen in lantana poisoning in ruminants.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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