Myocardial ischaemia following electrical stimulation of the left circumflex coronary artery in sheep: A role for thromboxane A2?

Cartcr J., Reynoldson J.A. and Thorburn G.D. (1986) Myocardial ischaemia following electrical stimulation of the left circumflex coronary artery in sheep: A role for thromboxane A2?. Comparative Biochemistry and Physiology. Part C, Comparative, 83 2: 393-399. doi:10.1016/0742-8413(86)90142-8


Author Cartcr J.
Reynoldson J.A.
Thorburn G.D.
Title Myocardial ischaemia following electrical stimulation of the left circumflex coronary artery in sheep: A role for thromboxane A2?
Journal name Comparative Biochemistry and Physiology. Part C, Comparative   Check publisher's open access policy
ISSN 0306-4492
Publication date 1986-01-01
Sub-type Article (original research)
DOI 10.1016/0742-8413(86)90142-8
Volume 83
Issue 2
Start page 393
End page 399
Total pages 7
Subject 2403 Immunology
3004 Pharmacology
Abstract 1. The electrical stimulation model of thrombus formation was tested on rabbit carotid artery and Actapted to sheep left circumflex coronary artery (LCCA). 2. LCCA blood flow, mean arterial pressure (MAP), heart rate (HR) and ECG were monitored continuously and arterial and coronary venous blood samples were taken for radioimmunoassay of thromboxane B2. 3. Stimulation of the LCCA mimicked acute myocardial infarction; reduction in LCCA blood flow preceded a fall in MAP and appearance of ECG abnormalities. 4. Thromboxane B2 levels rose by 126% 35min after stimulation. 5. These findings support the proposal by other authors that thromboxane plays an important role in the pathogenesis of acute myocardial infarction.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 05 Jul 2016, 14:52:54 EST by System User