Immune responses of infested and vaccinated Hereford cattle to antigens of the cattle tick, Boophilus microplus

Opdebeeck J.P. and Daly K.E. (1990) Immune responses of infested and vaccinated Hereford cattle to antigens of the cattle tick, Boophilus microplus. Veterinary Immunology and Immunopathology, 25 1: 99-108. doi:10.1016/0165-2427(90)90113-7


Author Opdebeeck J.P.
Daly K.E.
Title Immune responses of infested and vaccinated Hereford cattle to antigens of the cattle tick, Boophilus microplus
Journal name Veterinary Immunology and Immunopathology   Check publisher's open access policy
ISSN 0165-2427
Publication date 1990-01-01
Sub-type Article (original research)
DOI 10.1016/0165-2427(90)90113-7
Open Access Status Not Open Access
Volume 25
Issue 1
Start page 99
End page 108
Total pages 10
Subject 1103 Clinical Sciences
2403 Immunology
3400 Veterinary
Abstract Responses of infested and vaccinated Hereford cattle to Boophilus microplus antigens were measured by enzyme-linked immunosorbent assay (ELISA), lymphocyte blastogenesis assay (LBA) and intradermal skin tests. Responses against soluble salivary gland extracts (SGS), salivary gland membrane (SGM), soluble gut extracts (GS), gut membrane (GM), soluble larval extracts (LS) and larval membrane (LM) antigens were tested. In one experiment, cattle infested with up to 160 000 ticks had positive cellular responses to SGS and significant antibodies against LM, GM, SGM, and SGS. Cellular responses to Concanavalin A were not depressed following infestation. Cattle vaccinated with GM, using Quil A as adjuvant, had positive cellular responses to gut and salivary gland antigens and significant antibody responses to all antigens tested. The antibody levels of vaccinated cattle were significantly higher than the antibody levels of infested cattle (P < 0.05). In a second experiment, immune responses of cattle infested with 40 000 ticks were studied during 38 days. Cellular responses in LBA to several tick antigens were transiently elevated and significant levels of antibody were measured against LM, GM, SGM and SGS, from day 25 (P < 0.05). Infested cattle had positive skin reactions following intradermal injection of larval and adult tick antigens (P < 0.05).
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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