Effect of amitraz on contractions of the guinea-pig ileum in vitro

Pass M.A. and Seawright A.A. (1982) Effect of amitraz on contractions of the guinea-pig ileum in vitro. Comparative Biochemistry and Physiology. Part C, Comparative, 73 2: 419-422. doi:10.1016/0306-4492(82)90146-0


Author Pass M.A.
Seawright A.A.
Title Effect of amitraz on contractions of the guinea-pig ileum in vitro
Journal name Comparative Biochemistry and Physiology. Part C, Comparative   Check publisher's open access policy
ISSN 0306-4492
Publication date 1982-01-01
Sub-type Article (original research)
DOI 10.1016/0306-4492(82)90146-0
Volume 73
Issue 2
Start page 419
End page 422
Total pages 4
Subject 2403 Immunology
3004 Pharmacology
Abstract 1. 1. The effect of the formamidine pesticide amitraz on the motility of isolated pieces of guinea-pig ileum was studied. 2. 2. Contractions of the ileum stimulated by histamine and the histamine H1 agonists 2-methylhistamine and 2-pyridylethylamine were inhibited by amitraz at a concentration of 1 μg/ml. 3. 3. Amitraz did not inhibit contractions stimulated by acetylcholine, methacholine or dimethylphenylpiperazinium. 4. When pieces of intestine were left exposed to amitraz for several minutes they began to contract. These contractions appeared as rhythmic contractions and their strength did not appear to be increased by increasing the concentration of amitraz. 5. It is concluded that amitraz inhibits the action of histamine H1 agonists on the guinea-pig ileum and itself has a weak agonist effect.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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