The prolonged binding of ethyl carbamate-(14C) to DNA in regenerating and intact mouse liver

Lawson T.A. and Pound A.W. (1973) The prolonged binding of ethyl carbamate-(14C) to DNA in regenerating and intact mouse liver. European Journal of Cancer (1965), 9 7: 491-496. doi:10.1016/0014-2964(73)90133-3


Author Lawson T.A.
Pound A.W.
Title The prolonged binding of ethyl carbamate-(14C) to DNA in regenerating and intact mouse liver
Journal name European Journal of Cancer (1965)   Check publisher's open access policy
ISSN 0014-2964
Publication date 1973-01-01
Sub-type Article (original research)
DOI 10.1016/0014-2964(73)90133-3
Volume 9
Issue 7
Start page 491
End page 496
Total pages 6
Subject 2730 Oncology
Abstract The binding of ethyl carbamate-(1-14C), or a metabolite, to mouse liver DNA persisted longer if it was given to partially-hepatectomised mice compared with intact mice. Chromatographic examination of acid hydrolysates of the liver DNA from the partially hepatectomized mice showed that the radioactivity associated with the DNA was not present as a result of incorporation into the bases during DNA biosynthesis. Ethyl carbamate produced a greater inhibition of DNA turnover in the liver when given to partially-hepatectomized mice compared with intact mice.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 05 Jul 2016, 14:16:25 EST by System User