Laboratory evaluation of topically used antibiotics: Framycetin MIC and extinction time data for pseudomonas aeruginosa

Rawal B.D. (1987) Laboratory evaluation of topically used antibiotics: Framycetin MIC and extinction time data for pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy, 20 4: 537-540. doi:10.1093/jac/20.4.537


Author Rawal B.D.
Title Laboratory evaluation of topically used antibiotics: Framycetin MIC and extinction time data for pseudomonas aeruginosa
Journal name Journal of Antimicrobial Chemotherapy   Check publisher's open access policy
ISSN 0305-7453
Publication date 1987-01-01
Sub-type Article (original research)
DOI 10.1093/jac/20.4.537
Volume 20
Issue 4
Start page 537
End page 540
Total pages 4
Subject 1804 Statistics, Probability and Uncertainty
2604 Applied Mathematics
2737 Physiology (medical)
2725 Infectious Diseases
2736 Pharmacology (medical)
3004 Pharmacology
2404 Microbiology
Abstract Minimum inhibitory concentration (MIC) and extinction time (ET) of framycetin (0.5% in isotonic buffer) were determined. Of 90 consecutive clinical isolates of Pseudomonas aeruginosa, obtained from patients with ear or eye infections, 88.9% were inhibited by 62.5 mg/l and 96.66% were killed within 60 min by framycetin (0.5%). Determination of ET appears to be a promising technique for quantifying the bacterial action of high drug concentrations. Further clinical and experimental studies are required to see whether the ET predicts the efficacy of topical antibacterial preparations better than the MIC.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 05 Jul 2016, 12:55:07 EST by System User