Enhancement of hepatic drug metabolism by glutethimide in patients with liver disease

Farrell G.C., Cooksley W.G.E. and Powell L.W. (1979) Enhancement of hepatic drug metabolism by glutethimide in patients with liver disease. European Journal of Clinical Pharmacology, 16 2: 113-117. doi:10.1007/BF00563117

Author Farrell G.C.
Cooksley W.G.E.
Powell L.W.
Title Enhancement of hepatic drug metabolism by glutethimide in patients with liver disease
Journal name European Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0031-6970
Publication date 1979-01-01
Sub-type Article (original research)
DOI 10.1007/BF00563117
Volume 16
Issue 2
Start page 113
End page 117
Total pages 5
Publisher Springer-Verlag
Subject 3000 Pharmacology, Toxicology and Pharmaceutics
2736 Pharmacology (medical)
Abstract A controlled study of the effects of glutethimide on antipyrine metabolism was performed to ascertain how patients with varying degrees of liver damage responded to microsomal enzyme inducing agents. The administration of 250 mg glutethimide daily for one week resulted in significant enhancement of antipyrine metabolism in 4 patients with compensated cirrhosis and 5 patients with features of hepatic failure as well as 7 control subjects without liver disease. Even patients with very severe liver disease did undergo microsomal enzyme induction. Changes in antipyrine half-life after glutethimide were directly proportional to the original antipyrine half-life so that the greatest absolute alterations due to enzyme induction occurred in patients with the most severely impaired hepatic function. These results indicate that not only is antipyrine metabolism severely impaired in patients with liver failure, but elimination rates are markedly altered by enzyme inducing agents. Thus, although these results cannot be extrapolated to all inducers of hepatic microsomal enzymes nor to all drugs metabolized by microsomal oxidases, it is suggested that safe and effective management of drug therapy in these patients requires measurement of plasma levels.
Keyword antipyrine metabolism
drug therapy
enzyme induction
liver failure
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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